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PHYSIOLOGY ↔ KRIYA SHARIR

Agni / Digestion ↔ Gastric Secretion & GI Physiology

A mixed case: the avasthapaka digestion sequence and koshtha-based dosing are strong, well-grounded correspondences; the claims that ama is a specific pathological substance and that "all disease is caused by impaired agni" are not, and the source material says so plainly.

PHYSIOLOGY ↔ KRIYA SHARIR

Ojas / Vitality ↔ Immunity

The single most consequential overclaim tested in this exercise: ojas is not the immune system, and the source material is emphatic that reasoning otherwise has cost children's lives by discouraging vaccination.

PHYSIOLOGY ↔ KRIYA SHARIR

Nidra / Sleep ↔ Sleep Physiology

One of the best-correlated topics in this exercise on the general principle (sleep as an essential, actively-regulated pillar of health), with one specific, consequential, named gap: obstructive sleep apnea has no classical category and would be misclassified.

PHYSIOLOGY ↔ KRIYA SHARIR

Sapta Dhatu ↔ Tissue Formation and Nutritional Physiology

The three classical models of dhatu nourishment -- sequential delivery, selective uptake, and chemical transformation -- each capture a real modern mechanism, but the literal chain of one tissue physically forming the next is not a metabolic pathway; read instead as a hierarchy of nutritional priority, the framework's propagation principle and its ashtavidha sara assessment correspond well to the recognised pattern of tissue loss in chronic undernutrition and to modern nutritional examination.

PHYSIOLOGY ↔ KRIYA SHARIR

Rasa Dhatu ↔ Plasma and the Circulating Nutrient Fluid

Rasa dhatu's channel is correctly rooted in the heart and great vessels, and its described deficiency picture -- fatigue, dryness, pallor, palpitations and noise intolerance -- corresponds well to anaemia and malnutrition, but the framework has no concept of blood as cells suspended in a specific-composition fluid, so it cannot resolve what is actually deficient.

PHYSIOLOGY ↔ KRIYA SHARIR

Rakta Dhatu ↔ Blood and Haematology

Rakta dhatu's channel is rooted in the liver and spleen, the organs genuinely central to blood formation, destruction and pigment handling, and its deficiency picture is a recognisable description of anaemia, but the framework has no cellular concept and its therapeutic bloodletting (raktamokshana) has only a narrow, evidence-supported modern equivalent while being actively harmful in anaemia, coagulopathy and envenoming.

PHYSIOLOGY ↔ KRIYA SHARIR

Mamsa Dhatu ↔ Muscle Tissue and the Dhatu Sequence

Mamsa dhatu's covering (lepana) function and its anatomical peshi count match muscle's structural role, and its sara-assessment sites are exactly the sites of modern nutritional and cachexia examination, but the framework has no concept of the contraction mechanism or neural control needed to distinguish neurogenic from nutritional muscle wasting.

PHYSIOLOGY ↔ KRIYA SHARIR

Meda Dhatu ↔ Adipose Tissue Physiology and Obesity

Meda dhatu's three-way distinction of fat by location (general, intramuscular, marrow) and its account of obesity's causes and complications are substantially accurate by modern epidemiological standards, though its explanatory mechanism for the appetite-obesity cycle is not the modern one, and it lacks population-specific measurement thresholds and secondary-cause screening.

PHYSIOLOGY ↔ KRIYA SHARIR

Asthi Dhatu ↔ Bone Metabolism and Physiology

Asthi dhatu's account of bone as a supporting framework and its classification by shape correspond well to modern osteology, and its one exception to the general dosha-dhatu rule -- that bone and vata vary inversely -- correctly captures the association between ageing and bone loss, but the framework has no concept of bone as a living, hormonally regulated tissue.

PHYSIOLOGY ↔ KRIYA SHARIR

Majja Dhatu ↔ Bone Marrow and Central Nervous Tissue

Majja dhatu is correctly sited within the bones and joints, and its combined deficiency picture -- bone pain with giddiness -- recognisably describes coincident osteoporosis and anaemia; its classical usage also spans the central nervous system because the brain and cord lie within bone, an intelligible consequence of the framework's location-based definition rather than a confusion, though the framework never assigns majja the haemopoietic function itself.

PHYSIOLOGY ↔ KRIYA SHARIR

Shukra Dhatu ↔ Reproductive Physiology and Gametogenesis

Shukra dhatu's position last in the seven-tissue sequence correctly reflects that reproductive function is the first suppressed by undernutrition, illness, stress or exhaustion, and its descriptions of normal and abnormal semen are largely accurate, but its claim that shukra pervades the whole body is anatomically incorrect and the framework lacks the hypothalamic-pituitary-gonadal axis needed to diagnose a specific cause of infertility.

PHYSIOLOGY ↔ KRIYA SHARIR

Ashraya–Ashrayi Bhava ↔ Structure–Function Interdependency

The ashraya-ashrayi principle -- that each dosha varies together with its resident tissue, except for bone and vata, which vary inversely -- is a systematising concept rather than a statement of biochemical mechanism, though three of its specific pairings (pitta-blood, kapha-fat, vata-bone-in-ageing) correspond to real clinical associations.

PHYSIOLOGY ↔ KRIYA SHARIR

Upadhatu ↔ Secondary Tissue Physiology

Several upadhatu descriptions are observationally precise -- the stimuli described for milk let-down match the modern milk-ejection reflex, and the non-staining criterion for normal menstrual blood is a genuine rough test of excess bleeding -- but each secondary tissue's classical account lacks the underlying hormonal mechanism needed to diagnose why lactation, menstruation or fertility has failed.

PHYSIOLOGY ↔ KRIYA SHARIR

Mala ↔ Excretory Physiology and Waste Elimination

The classical principle that bodily wastes serve supportive functions until eliminated, so that excessive elimination is as harmful as retention, is a genuine safety principle that modern medicine endorses, and the rule against suppressing the urge to defecate has a demonstrable physiological basis, but the classical account of urine formation places it in the intestine rather than the kidney, which is anatomically incorrect.

PHYSIOLOGY ↔ KRIYA SHARIR

Kapha Dosha ↔ Connective Tissue, Mucosal & Lubricative Physiology

Kapha, the classical principle of cohesion and lubrication, maps onto real protective/lubricating fluids at its five sites, most clearly synovial fluid at the joints; kapha excess also overlaps strongly with hypothyroidism.

PHYSIOLOGY ↔ KRIYA SHARIR

Dosha Vriddhi-Kshaya ↔ Physiological Excess & Deficiency States

The classical model of dosha increase (vriddhi) and decrease (kshaya), governed by samanya-vishesha, parallels modern excess/deficiency physiology but groups distinct conditions under non-specific symptom clusters.

PHYSIOLOGY ↔ KRIYA SHARIR

Prakriti ↔ Individual Physiological & Genetic Variation

Prakriti, the constitution fixed at conception, structurally parallels genetic-plus-developmental models of individual variation, and preliminary ayurgenomics research reports gene-expression differences between prakriti types.

PHYSIOLOGY ↔ KRIYA SHARIR

Sharira & Manasa Dosha ↔ Mind-Body Physiological Framework

Classical Ayurveda defines the person as body-senses-mind-self and names two dosha systems (three bodily, two mental), building psychosomatic medicine into its foundations rather than adding it later.

PHYSIOLOGY ↔ KRIYA SHARIR

Dosha-Dhatu-Mala & Srotas ↔ Regulatory, Tissue, and Transport Systems

Ayurveda's three-way division of the body into regulators, tissues, and wastes, linked by srotas (channels), parallels modern physiology's division into regulatory systems, tissues, and transport pathways, but lacks measurement and specific diagnosis.

PHYSIOLOGY ↔ KRIYA SHARIR

Tridosha ↔ Physiological Regulation and Biological Rhythms

The tridosha model organizes physiology into three functional principles — movement, transformation, cohesion — and predicts disease timing by hour, season, and age, correspondences that map loosely onto modern chronobiology but not onto specific measurable substances.

PHYSIOLOGY ↔ KRIYA SHARIR

Vata Dosha ↔ Nervous System and Neuromuscular Function

Vata's description as the sole mobile, controlling principle governing movement, sensation, cognition, and elimination closely parallels nervous system function, with its five sub-types loosely corresponding to cranial, motor, digestive-motility, circulatory, and eliminative control — but without anatomical localization of lesions.

PHYSIOLOGY ↔ KRIYA SHARIR

Pitta Dosha ↔ Metabolic and Digestive-Hepatic Physiology

Pitta's function of transformation — digestion, metabolism, heat, blood pigment handling, vision, and complexion — maps loosely onto modern digestive and hepatic physiology, with a genuinely good localization (liver/spleen for blood pigment) alongside a clearly incorrect one (mind located in the heart).